Serial Microbiota Analysis after Fecal Microbiota Transplantation in a Child with Down's Syndrome
| Autor: | Clementien L. Vermont, Yvette H. van Beurden, Andries E. Budding, Tim G. J. de Meij, Lisethe Meijer, Chris J. J. Mulder |
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| Přispěvatelé: | VU University medical center, Medical Microbiology and Infection Prevention, AGEM - Digestive immunity, AII - Infectious diseases, Gastroenterology and hepatology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Firmicutes
CLOSTRIDIUM-DIFFICILE INFECTION 03 medical and health sciences 0302 clinical medicine Clostridium difficile infection 030225 pediatrics Medicine Fidaxomicin Microbiome Down's syndrome Feces child biology business.industry Verrucomicrobia fecal microbiota transplantation Bacteroidetes Fusobacteria microbiota analysis Clostridium difficile biology.organism_classification Infectious Diseases TUBE Pediatrics Perinatology and Child Health Immunology RISK-FACTORS 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Journal of pediatric infectious diseases, 14(3), 136-139. GEORG THIEME VERLAG KG JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, 14(3), 136-139. IOS Press Beurden, Y H V, Meijer, L, Vermont, C L, Budding, A E, Mulder, C J J & Meij, T G D 2019, ' Serial Microbiota Analysis after Fecal Microbiota Transplantation in a Child with Down's Syndrome ', JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, vol. 14, no. 3, pp. 136-139 . https://doi.org/10.1055/s-0037-1606330 |
| ISSN: | 1305-7707 |
| Popis: | Fecal microbiota transplantation (FMT) is a very effective treatment for recurrent Clostridium difficile infection (CDI) in adults. However, there is a paucity of data on FMT in children and associated microbiome changes in this particular group. We describe a child with Down's syndrome and intracranial malignancy, who received FMT for recurrent CDI. Detailed microbiota analysis before and after FMT, and pre- and post-recurrence, linked to microbial communities in the donor feces showed that the patient developed a unique microbiota profile after FMT which was very stable over time despite CDI recurrence and subsequent fidaxomicin therapy. Bacteroidetes were stably acquired from donor feces, while Firmicutes, Actinobacteria, Fusobacteria, Verrucomicrobia, and Proteobacteria were unique to the patient. The diversity of microbiota of the patient increased from a Shannon diversity index of 2.08 pre-FMT to 3.12 post-FMT. Our findings underscore that patients with Down's syndrome may well tolerate and benefit from FMT even in a severely immunocompromised state. |
| Databáze: | OpenAIRE |
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