Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
| Autor: | Carmine Di Iorio, Erica Cecilia Priori, Paola Rossi, Elisa Roda, Elena Savino, Paola Angelone, Fabrizio De Luca, Carlo Locatelli, Daniela Ratto, Lorenzo Goppa, Anthea Desiderio, Maria Grazia Bottone |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cerebellum Hericium Nitric Oxide Synthase Type II Pharmacology medicine.disease_cause Systemic inflammation Sirtuin 1 Hericium erinaceus Medicine oxidative stress Cognitive decline Biology (General) Spectroscopy biology Erinaceus General Medicine Computer Science Applications Chemistry medicine.anatomical_structure healthy aging neuroprotection medicine.symptom cerebellum QH301-705.5 Inflammation frailty Motor Activity Neuroprotection Catalysis Article Inorganic Chemistry Glial Fibrillary Acidic Protein Animals inflammaging Physical and Theoretical Chemistry Molecular Biology QD1-999 business.industry Interleukin-6 Plant Extracts Superoxide Dismutase Organic Chemistry ergothioneine biology.organism_classification Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Cyclooxygenase 2 business Oxidative stress |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 12 International Journal of Molecular Sciences, Vol 22, Iss 6379, p 6379 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22126379 |
| Popis: | Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., inflammaging. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of H. erinaceus, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathways, were assessed focusing on senescent frail animals. H. erinaceus partially recovered the aged-related decline of locomotor performances. Histopathological analyses paralleled by immunocytochemical evaluation of specific molecules strengthened the neuroprotective role of H. erinaceus able to ameliorate cerebellar alterations, i.e., milder volume reduction, slighter molecular layer thickness decrease and minor percentage of shrunken Purkinje neurons, also diminishing inflammation and oxidative stress in frail mice while increasing a key longevity regulator and a neuroprotective molecule. Thus, our present findings demonstrated the efficacy of a non-pharmacological approach, based on the dietary supplementation using H. erinaceus extract, which represent a promising adjuvant therapy to be associated with conventional geriatric treatments. |
| Databáze: | OpenAIRE |
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