Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer
| Autor: | Nils Elander, Karin Fransén, Peter Söderkvist |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Genotype Colorectal cancer Nitric Oxide Synthase Type II Polymerase Chain Reaction law.invention Nitric oxide chemistry.chemical_compound law parasitic diseases medicine Humans Genetic Predisposition to Disease Promoter Regions Genetic neoplasms Genotyping Gene Polymerase chain reaction Polymorphism Single-Stranded Conformational Polymorphism Genetic biology Nitric oxide synthase 2 respiratory system medicine.disease Molecular biology digestive system diseases Oncology chemistry Cancer research biology.protein Disease Progression Restriction fragment length polymorphism Nitric Oxide Synthase Colorectal Neoplasms Polymorphism Restriction Fragment Length |
| Zdroj: | Cancer letters. 225(1) |
| ISSN: | 0304-3835 |
| Popis: | Previously, increased expression of nitric oxide synthase 2 (NOS2) in colorectal cancer (CRC) has been identified. The NOS2 gene is transcriptionally regulated, which suggests that polymorphisms in the NOS2 promoter may have a role for CRC development and progression. The genotyping was performed with PCR/RFLP, single strand conformation analysis or MegaBACE genotyping of normal blood DNA from CRC patients and normal healthy controls. However, no significant association between NOS2 polymorphisms and CRC onset or clinical outcome was evident. In conclusion, these results, therefore, suggest that NOS2 promoter polymorphisms have a limited effect on the onset or progression of CRC. |
| Databáze: | OpenAIRE |
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