Gene-Related Response of Basal Cell Carcinoma to Biologic Treatment with Vismodegib

Autor:	Amir Sternfeld, Moran Friedman-Gohas, Dean Ad El, Yoav Vardizer, Jacob Bejar, Shirel Rosenwasser-Weiss, Hila Kreizman Shefer, Gil Tauber, Asaf Olshinka, Iftach Yassur, Nitza Goldenberg-Cohen, Gur Ben-Yehuda
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Oncology Male medicine.medical_specialty Pyridines Vismodegib Gene Expression lcsh:Medicine Antineoplastic Agents Cell Cycle Proteins GPI-Linked Proteins Article GLIS2 Internal medicine Biopsy medicine Carcinoma Cancer genomics Biomarkers Tumor Humans Basal cell carcinoma Anilides Hedgehog Proteins skin and connective tissue diseases lcsh:Science Gene Cancer genetics Aged Regulation of gene expression Aged 80 and over Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Middle Aged medicine.disease Hedgehog signaling pathway Gene Expression Regulation Neoplastic Treatment Outcome Carcinoma Basal Cell Disease Progression Female lcsh:Q business Transcriptome medicine.drug Signal Transduction
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-58117-0
Popis:	We aimed to characterise the response of locally advanced basal cell carcinoma (BCC) to systemic treatment with Vismodegib, a Hedgehog pathway inhibitor, by changes in the expression levels of Hedgehog pathway genes. Data were collected prospectively on 12 patients treated systemically for locally advanced BCC. Biopsy samples taken on admission and after treatment cessation were analysed pathologically and with the NanoString nCounter system to quantify the expression of 40 Hedgehog signaling pathway genes. Findings were compared before and after treatment, between complete and partial responders, and with localised BCC samples from 22 patients. Sixteen Hedgehog pathway genes changed significantly from before to after treatment. GAS1 was the only gene with a significantly different expression at baseline between complete responders (6 patients) and partial responders (4 patients) to Vismodegib (P = 0.014). GAS, GLIS2 and PRKACG1 showed different expression before treatment between the locally advanced and localised BCCs. The baseline expression level of GAS1 appears to be predictive of the response of locally advanced BCC to systemic Vismodegib treatment. A change in expression of many Hedgehog pathway genes, albeit expected by the known activity of Vismodegib, may nevertheless serve as an indicator of the response potential of the tumour.
Databáze:	OpenAIRE
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