Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon
| Autor: | Lívia M. Carvalho, Cláudia Martins Carneiro, Paula Melo de Abreu Vieira, Thais Vieira de Carvalho, João Vitor Madeira, Kátia da Silva Fonseca, Rodrigo Correa-Oliveira, Israel Molina, Luciana da Fonseca Medeiros, Luísa Perin |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Colon Trypanosoma cruzi 030231 tropical medicine Immunology Chronic Chagas' disease Disease Real-Time Polymerase Chain Reaction Gastroenterology 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Animals Chagas Disease Cyclophosphamide Immunosuppression Therapy biology Treatment regimen Low dose Neglected Diseases Heart General Medicine 030108 mycology & parasitology biology.organism_classification Trypanocidal Agents Treatment efficacy Infectious Diseases Blood Benznidazole Nitroimidazoles Acute Disease Chronic Disease Parasitology Female medicine.drug |
| Zdroj: | Experimental parasitology. 210 |
| ISSN: | 1090-2449 |
| Popis: | Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma cruzi Y strain in the acute and chronic phases of Chagas' disease. Our findings indicate that an experimental treatment with a BNZ low-dose (40 mg/kg/day) is similarly effective as the usual dose in the chronic mice model (100% of cure). In addition, the treatment in the chronic model of Chagas' disease presented better results than the acute model and colon appears to be a key tissue when it comes to evaluating treatment efficacy compared to blood and heart. Therefore, our data suggest the reconsideration of the current therapy, mainly in the chronic phase of the disease. |
| Databáze: | OpenAIRE |
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