Health implication of vitamin D on the cardiovascular and the renal system
| Autor: | Raghad Khalid Al-Ishaq, Katarina Gazdikova, Peter Kubatka, Martin Caprnda, Dietrich Büsselberg, Martina Brozmanova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Physiology chemistry.chemical_element 030209 endocrinology & metabolism Disease Calcium Kidney Cardiovascular System Calcitriol receptor vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Immune system Ventricular hypertrophy Physiology (medical) Internal medicine medicine Vitamin D and neurology Humans Vitamin D business.industry General Medicine medicine.disease Endocrinology chemistry Health Apoptosis 030220 oncology & carcinogenesis Dietary Supplements business |
| Zdroj: | Archives of Physiology and Biochemistry. 127:195-209 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | Vitamin D regulates the calcium and phosphorus balance in the body. The activated form of vitamin D (1 α,25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis. In the cardiovascular system, the vitamin D receptor is present in cardiomyocytes and the arterial wall. A clear correlation between vitamin D level and cardiovascular diseases is established. Vitamin D deficiency affects the renin-angiotensin system leading to ventricular hypertrophy and eventually to stroke. While clinical trials highlighted the positive effects of vitamin D supplements on cardiovascular disease these still need to be confirmed. This review outlines the association between vitamin D and cardiovascular and renal disease summarising the experimental data of selective cardiovascular disorders. |
| Databáze: | OpenAIRE |
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