Regional distribution of dopamine D4 receptors in rat forebrain
| Autor: | Ross J. Baldessarini, Frank I. Tarazi, Nora S. Kula |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Hippocampus Nucleus accumbens Tritium Rats Sprague-Dawley Radioligand Assay chemistry.chemical_compound Prosencephalon Dopamine Radioligand medicine Animals Receptor Receptors Dopamine D2 Chemistry General Neuroscience Receptors Dopamine D4 Nemonapride Entorhinal cortex Molecular biology Rats Organ Specificity Dopamine receptor Benzamides Autoradiography Dopamine Antagonists Neuroscience medicine.drug |
| Zdroj: | NeuroReport. 8:3423-3426 |
| ISSN: | 0959-4965 |
| Popis: | BINDING of the D 2 -like (D 2 /D 3 /D 4 ) radioligand [ 3 H]nemonapride under selective conditions (with 300 nM S[-]-raclopride and other masking agents to occlude D 2 /D 3 receptors and non-specific binding sites) revealed a subset of raclopride-insensitive binding sites considered D 4 -like receptors. These sites were stereoselective to R(-)-N-n-propylnorapomorphine (NPA) over its S(+)-NPA in a similar fashion to cloned D 4 receptors expressed in cell lines. In addition, the highly D 4 -selective agent L-745,870 displaced 74-83% of these sites in rat brain regions, suggesting that most were D 4 receptors. These apparent D 4 receptors represented a relatively high proportion of D 2 -like receptors in hippocampus, dorsolateral frontal, medial prefrontal and entorhinal cortex, but fewer in caudate-putamen and nucleus accumbens. |
| Databáze: | OpenAIRE |
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