Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
| Autor: | W. K. Eddie Ip, Kathryn J. Moore, R. Alan B. Ezekowitz, Kazue Takahashi, Lynda M. Stuart |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Staphylococcus aureus
Immunology Protein Array Analysis Immune receptor Biology Mannose-Binding Lectin Models Biological Article Cell Line Evolution Molecular 03 medical and health sciences Mice 0302 clinical medicine Immune system Phagosomes Immunology and Allergy Animals Humans Complement Activation 030304 developmental biology Phagosome Mannan-binding lectin 0303 health sciences Toll-like receptor Innate immune system Pattern recognition receptor Cell Biology Articles Immunity Innate Toll-Like Receptor 2 3. Good health Cell biology Mice Inbred C57BL Toll-Like Receptor 6 Immune System Signal transduction 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune response demonstrates surprising specificity to different pathogens. We determined how combinatorial use of innate immune defense mechanisms defines the response. We describe a novel cooperation between a soluble component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that both specifies and amplifies the host response to Staphylococcus aureus. Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways. |
| Databáze: | OpenAIRE |
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