A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese
| Autor: | Katsuki Kono, Shohei Minami, Nobuyuki Fujita, Kota Watanabe, Taichi Tsuji, Mitsuru Yagi, Atsushi Miyake, Masahiro Nakajima, Shiro Ikegawa, Yoji Ogura, Ikuho Yonezawa, Tsuyoshi Sakuma, Hideki Sudo, Morio Matsumoto, Naobumi Hosogane, Haruhisa Yanagida, Masaya Nakamura, Toshiaki Kotani, Teppei Suzuki, Kazuhiro Chiba, Yohei Takahashi, Katsumi Harimaya, Ikuyo Kou, Kazuki Takeda, Takashi Kaito, Noriaki Kawakami, Tsutomu Akazawa, Manabu Ito, Eijiro Okada, Yuki Taniguchi, Hideki Shigematsu, Satoru Demura, Takahiro Iida, Kei Watanabe, Kenichiro Kakutani, Kotaro Nishida, Hiroshi Taneichi, Koki Uno |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Adolescent Genotype Single-nucleotide polymorphism Idiopathic scoliosis Genome-wide association study Scoliosis Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Japan Severity of illness Medicine Humans Orthopedics and Sports Medicine Association (psychology) Child Genetic Association Studies business.industry Skeletal maturity medicine.disease 030104 developmental biology Physical therapy Female Neurology (clinical) business Risser sign 030217 neurology & neurosurgery |
| Zdroj: | Spine. 43(10) |
| ISSN: | 1528-1159 |
| Popis: | Case-only study.The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS.Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies.A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups.The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51).We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association.4. |
| Databáze: | OpenAIRE |
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