Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: Results from a prospective multinational study

Autor: Najia Hajjaj-Hassouni, Hassane Awada, M.A.F.J. van de Laar, Maxime Dougados, Claire Bombardier, David T. Felson, Nicholas Bellamy, M. Hochberg, D. van der Heijde, Emilio Martín-Mola, Florence Tubach, Marco Matucci-Cerinic, Philippe Ravaud, Isabelle Logeart
Přispěvatelé: Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Investigation Clinique - Epidémiologie Clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-PRES Sorbonne Paris Cité-Institut National de la Santé et de la Recherche Médicale (INSERM), Rheumatology Department, Universidad Autónoma de Madrid (UAM)-Hospital Universitario La Paz, Université Saint-Joseph de Beyrouth (USJ)-Hotel-Dieu de France Hospital, Centre of National Research on Disability and Rehabilitation Medicine (CONROD), University of Queensland [Brisbane]-Royal Brisbane and Women's Hospital, Institute for Work and Health (IWH), University of Toronto-St. Michael's Hospital-Institute of Medical Sciences, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine (BUSM), Boston University [Boston] (BU)-Boston University [Boston] (BU)-Arthritis Center, Rheumatology and Physical Rehabilitaion Department, Université Mohammed V de Rabat [Agdal] (UM5)-El Ayachi Hospital, Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, University of Maryland System-University of Maryland System, Pfizer France, Pfizer, Departments of Medicine, Biomedicine & Rheumatology, Università degli Studi di Firenze = University of Florence (UniFI)-Division of Rheumatology AOUC - Denothe Centre, Department of Rheumatology, Arthritis Centre Twente-University of Twente and Medisch Spectrum Twente, University Hospital Maastricht, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gillet, Catherine, Faculty of Behavioural, Management and Social Sciences, Psychology, Health & Technology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-PRES Sorbonne Paris Cité-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Autonoma de Madrid (UAM)-Hospital Universitario La Paz, University of Mohammed V-El Ayachi Hospital, Pfizer Ltd France, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)-Division of Rheumatology AOUC - Denothe Centre, Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques, Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris] - PRES Sorbonne Paris Cité - Institut National de la Santé et de la Recherche Médicale (INSERM) - AP-HP, Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz, Université Saint-Joseph de Beyrouth (USJ) - Hotel-Dieu de France Hospital, University of Queensland [Brisbane] - Royal Brisbane and Women's Hospital, University of Toronto - St. Michael's Hospital - Institute of Medical Sciences, Boston University School of Medicine - Arthritis Center, University of Mohammed V - El Ayachi Hospital, Pfizer SAS, Division of Rheumatology AOUC - Denothe Centre - University of Florence, Arthritis Centre Twente - University of Twente and Medisch Spectrum Twente, Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP]
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
rheumatoid arthritis
Percentile
Internationality
MESH : Aged
MESH : Prospective Studies
MESH : Spondylitis
Ankylosing
MESH : Rheumatic Diseases
Osteoarthritis
Severity of Illness Index
Osteoarthritis
Hip
MESH: Rheumatic Diseases
Arthritis
Rheumatoid
Cohort Studies
Disability Evaluation
0302 clinical medicine
MESH : Back Pain
reflect
Back pain
MESH: Osteoarthritis
Knee
MESH : Female
030212 general & internal medicine
Prospective Studies
MESH: Cohort Studies
MESH: Treatment Outcome
MESH: Aged
MESH: Arthritis
Rheumatoid
IR-83841
MESH: Middle Aged
MESH: Disability Evaluation
MESH : Adult
Middle Aged
Osteoarthritis
Knee
MESH: Spondylitis
Ankylosing
3. Good health
Treatment Outcome
Patient Satisfaction
Rheumatoid arthritis
MESH : Severity of Illness Index
Female
medicine.symptom
MESH : Osteoarthritis
Hip
Chronic Pain
Cohort study
Adult
medicine.medical_specialty
MESH : Patient Satisfaction
MESH : Male
MESH : Chronic Pain
MESH : Cohort Studies
MESH : Disability Evaluation
MESH : Treatment Outcome
03 medical and health sciences
MESH : Internationality
Rheumatology
Rheumatic Diseases
MESH: Severity of Illness Index
ankylosing spondylitis
medicine
Humans
MESH : Middle Aged
Spondylitis
Ankylosing
METIS-291293
MESH : Osteoarthritis
Knee
Aged
030203 arthritis & rheumatology
Ankylosing spondylitis
MESH: Humans
business.industry
MESH : Humans
MESH: Adult
medicine.disease
PASS
Confidence interval
MESH: Male
MESH: Patient Satisfaction
MESH: Prospective Studies
MICC
Back Pain
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
MESH : Arthritis
Rheumatoid
MESH: Back Pain
Physical therapy
MESH: Internationality
MESH: Chronic Pain
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Osteoarthritis
Hip
business
MESH: Female
Hand osteoarthritis
Zdroj: Arthritis Care & Research = Arthritis Care and Research
Arthritis Care & Research = Arthritis Care and Research, 2012, 64 (11), pp.1699-707. ⟨10.1002/acr.21747⟩
Arthritis care & research, 64(11), 1699-1707. Wiley
Arthritis Care & Research = Arthritis Care and Research, Wiley-Blackwell, 2012, 64 (11), pp.1699-707. ⟨10.1002/acr.21747⟩
Arthritis Care and Research
Arthritis Care and Research, Wiley-Blackwell, 2012, 64 (11), pp.1699-707. 〈10.1002/acr.21747〉
ISSN: 0893-7524
1529-0123
2151-464X
DOI: 10.1002/acr.21747⟩
Popis: International audience; OBJECTIVE: To estimate the minimum clinically important improvement (MCII) and patient acceptable symptom state (PASS) values for 4 generic outcomes in 5 rheumatic diseases and 7 countries. METHODS: We conducted a multinational (Australia, France, Italy, Lebanon, Morocco, Spain, and The Netherlands) 4-week cohort study involving 1,532 patients who were prescribed nonsteroidal antiinflammatory drugs for ankylosing spondylitis, chronic back pain, hand osteoarthritis, hip and/or knee osteoarthritis, or rheumatoid arthritis. The MCII and PASS values were estimated with the 75th percentile approach for 4 generic outcomes: pain, patient global assessment, functional disability, and physician global assessment, all normalized to a 0-100 score. RESULTS: For the whole sample, the estimated MCII values for absolute change at 4 weeks were -17 (95% confidence interval [95% CI] -18, -15) for pain; -15 (95% CI -16, -14) for patient global assessment; -12 (95% CI -13, -11) for functional disability assessment; and -14 (95% CI -15, -14) for physician global assessment. For the whole sample, the estimated PASS values were 42 (95% CI 40, 44) for pain; 43 (95% CI 41, 45) for patient global assessment; 43 (95% CI 41, 44) for functional disability assessment; and 39 (95% CI 37, 40) for physician global assessment. Estimates were consistent across diseases and countries (for subgroups ≥20 patients). CONCLUSION: This work allows for promoting the use of values of MCII (15 of 100 for absolute improvement, 20% for relative improvement) and PASS (40 of 100) in reporting the results of trials of any of the 5 involved rheumatic diseases with pain, patient global assessment, physical function, or physician global assessment used as outcome criteria.
Databáze: OpenAIRE
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