Tolerance of the Spinal Cord to Stereotactic Radiosurgery: Insights From Hemangioblastomas
| Autor: | Clara Y.H. Choi, Scott G. Soltys, Megan E. Daly, John R. Adler, Robert E. Lieberson, Steven D. Chang, Iris C. Gibbs |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research Foot drop Cord medicine.medical_treatment Central nervous system Radiosurgery Radiation Tolerance Effective dose (radiation) Young Adult Hemangioblastoma medicine Humans Radiology Nuclear Medicine and imaging Spinal Cord Neoplasms Rachis Retrospective Studies Radiation business.industry Radiotherapy Dosage Middle Aged Spinal cord medicine.disease Tumor Burden medicine.anatomical_structure Spinal Cord Oncology Female medicine.symptom Nuclear medicine business Relative Biological Effectiveness |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 80:213-220 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2010.01.040 |
| Popis: | Purpose To evaluate spinal cord dose–volume effects, we present a retrospective review of stereotactic radiosurgery (SRS) treatments for spinal cord hemangioblastomas. Methods and Materials From November 2001 to July 2008, 27 spinal hemangioblastomas were treated in 19 patients with SRS. Seventeen tumors received a single fraction with a median dose of 20 Gy (range, 18–30 Gy). Ten lesions were treated using 18–25 Gy in two to three sessions. Cord volumes receiving 8, 10, 12, 14, 16, 18, 20, 22, and 24 Gy and dose to 10, 100, 250, 500, 1000, and 2000 mm 3 of cord were determined. Multisession treatments were converted to single-fraction biologically effective dose (SFBED). Results Single-fraction median cord D max was 22.7 Gy (range, 17.8–30.9 Gy). Median V10 was 454 mm 3 (range, 226–3543 mm 3 ). Median dose to 500 mm 3 cord was 9.5 Gy (range, 5.3–22.5 Gy). Fractionated median SFBED 3 cord D max was 14.1 Gy 3 (range, 12.3–19.4 Gy 3 ). Potential toxicities included a Grade 2 unilateral foot drop 5 months after SRS and 2 cases of Grade 1 sensory deficits. The actuarial 3-year local tumor control estimate was 86%. Conclusions Despite exceeding commonly cited spinal cord dose constraints, SRS for spinal hemangioblastomas is safe and effective. Consistent with animal experiments, these data support a partial-volume tolerance model for the human spinal cord. Because irradiated cord volumes were generally small, application of these data to other clinical scenarios should be made cautiously. Further prospective studies of spinal radiosurgery are needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|