Association of X4 tropism with disease progression in antiretroviral-treated children and adolescents living with HIV/AIDS in São Paulo, Brazil
| Autor: | Marco Aurélio Palazzi Sáfadi, Denise Helena Moreira, Mayra Simioni Zaparoli, Jaqueline de Souza Cavalcanti, Eitan Naaman Berezin, João Leandro de Paula Ferreira, Flávia Jacqueline Almeida, Rosangela Rodrigues, Luís Fernando de Macedo Brígido |
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| Jazyk: | angličtina |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Receptors CXCR4 Adolescent Genotype Treatment adherence Population lcsh:QR1-502 Viremia HIV Infections Biology CXCR4 lcsh:Microbiology lcsh:Infectious and parasitic diseases Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine Humans lcsh:RC109-216 education Child Children Tropism Viral tropism Medicine(all) education.field_of_study Disease progression Infant virus diseases Viral Load medicine.disease CD4 Lymphocyte Count Infectious Diseases Anti-Retroviral Agents Child Preschool Immunology Tissue tropism HIV-1 RNA Viral Female |
| Zdroj: | Brazilian Journal of Infectious Diseases v.18 n.3 2014 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 18, Issue: 3, Pages: 300-307, Published: JUN 2014 Brazilian Journal of Infectious Diseases, Vol 18, Iss 3, Pp 300-307 (2014) |
| ISSN: | 1413-8670 |
| DOI: | 10.1016/j.bjid.2013.10.002 |
| Popis: | Management of children with HIV/AIDS is specially challenging. Age-related issues do not allow for direct transposition of adult observations to this population. CXCR4 tropism has been associated with disease progression in adults. The geno2pheno web-base is a friendly tool to predict viral tropism on envelope V3 sequences, generating a false positive rate for a CXCR4 prediction. We evaluated the association of HIV-1 tropism prediction with clinical and laboratory outcome of 73 children with HIV/AIDS in São Paulo, Brazil. The CXCR4 tropism was strongly associated with a lower (nadir) CD4 documented during follow-up (p |
| Databáze: | OpenAIRE |
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