Single Dose Intravesical Thiotepa as an Adjuvant to Cystodiathermy in the Treatment of Transitional Cell Bladder Carcinoma
| Autor: | M. E. Mayo, P. J. R. Boyd, K. E. D. Shuttleworth, K. G. Burnand, R. W. Lloyd-Davies |
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| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Urology medicine.medical_treatment ThioTEPA Cystodiathermy Recurrent Tumor Electrocoagulation Humans Medicine Recurrent tumour Carcinoma Transitional Cell Clinical Trials as Topic business.industry Incidence (epidemiology) Middle Aged Tumor recurrence Transitional cell bladder carcinoma Urinary Bladder Neoplasms Female Neoplasm Recurrence Local Urinary Catheterization business Adjuvant Thiotepa Follow-Up Studies medicine.drug |
| Zdroj: | British Journal of Urology. 48:55-59 |
| ISSN: | 1464-410X 0007-1331 |
| DOI: | 10.1111/j.1464-410x.1976.tb02742.x |
| Popis: | Tumour cell implantation may be a factor in the aetiology of recurrent well-differentiated superficial bladder tumours. A prospective trial is reported in which single dose intravesical thiotepa was administered to a group of randomly selected patients immediately after cystodiathermy. A control group of patients was treated by cystodiathermy alone and tumour recurrence in the 2 groups was compared. Significantly fewer patients in the thiotepa-treated group developed recurrent tumour and there was also a significantly reduced incidence of pure vault recurrence in this group. The beneficial effects of adjuvant thiotepa were apparent after 1 treatment. In this series of patients no benefit resulted from the continued use of adjuvant thiotepa once a patient developed a recurrent tumor. |
| Databáze: | OpenAIRE |
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