Intermittent theta burst stimulation over left BA10 enhances virtual reality-based prospective memory in healthy aged subjects

Autor: Anne-Marie Ergis, Sylvain Charron, Maria Abram, Pauline Roca, Bernard Gueguen, Stéphanie Lion, Benoît Crépon, Catherine Oppenheim, Eric Orriols, Pascale Piolino, Jean-Claude Baron, Ursula Debarnot
Přispěvatelé: Centre de Recherche et d'Innovation sur le Sport (EA647) (CRIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), LABORATOIRE DE PSYCHOLOGIE EXPÉRIMENTALE, Université Paris Descartes - Paris 5 (UPD5), Centre de recherche en épistémologie appliquée (CREA), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Psychologie et Neuropsychologie Cognitives (LPNCog FRE 3292), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Department of Clinical Neurosciences [Cambridge], University of Cambridge [UK] (CAM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Psychiatrie et Neurosciences (U894)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2015, 36 (8), pp.2360-2369. ⟨10.1016/j.neurobiolaging.2015.05.001⟩
Neurobiology of Aging, 2015, 36 (8), pp.2360-2369. ⟨10.1016/j.neurobiolaging.2015.05.001⟩
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2015.05.001⟩
Popis: Prospective memory (PM) refers to a complex cognitive ability that underpins the delayed execution of previously formulated intentions. PM performance declines early in normal aging and this process is accentuated in Alzheimer's disease. The left frontopolar cortex (BA10) has been consistently assigned a major role in PM functioning, but whether it can be noninvasively modulated to enhance PM perfor- mance in aged people has not been addressed so far. Here, we investigated the effects of modulating left BA10 by means of theta burst stimulation (TBS), using either excitatory (intermittent TBS), inhibitory (continuous TBS) or control (vertex) TBS in healthy aged subjects. The behavioral effects were assessed using a reliable and ecological virtual reality PM task that included both event- and time-based retrievals. As compared with vertex stimulation, event-based PM performance significantly improved after excit- atory stimulation, whereas inhibitory stimulation had no significant effect. Additionally, and across the different types of stimulation, performance for congruent links between the event-based PM cue and the action to be performed was significantly better as compared with incongruent links. In conclusion, intermittent TBS might provide a relevant interventional strategy to counteract the decline of cognitive functions and memory abilities in normal aging.
Databáze: OpenAIRE
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