New Insights into the Management of Patients with Autoimmune Diseases or Inflammatory Disorders During Pregnancy
| Autor: | Ghazal Rahimzadeh, Soheil Tavakolpour |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Multiple Sclerosis Immunology Arthritis Antibodies Monoclonal Humanized Dermatitis Atopic Arthritis Rheumatoid 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system Th2 Cells Hygiene hypothesis Adrenal Cortex Hormones Pregnancy Psoriasis medicine Humans Lupus Erythematosus Systemic Autoimmune disease Lupus erythematosus business.industry Antibodies Monoclonal Disease Management Microchimerism General Medicine Th1 Cells medicine.disease Asthma Pemphigus 030104 developmental biology Th17 Cells Female business |
| Zdroj: | Scandinavian journal of immunology. 84(3) |
| ISSN: | 1365-3083 |
| Popis: | The treatment of autoimmune diseases remains a serious problem. Current therapies can lead to adverse effects in patients. One of the most vulnerable patient groups is pregnant women. It has been reported that different autoimmune diseases have a certain trend during pregnancy and after delivery which could be explained by maternal immune responses. Better management of pregnant women with autoimmune diseases or inflammatory disorders could be achieved by linking such alterations in immune responses and governed immune responses in different autoimmune disorders while considering various reports of autoimmune conditions during pregnancy. This study considers changing the T helper cells (Th1) and Th2 balance and suggests some new approaches for the better management of autoimmune diseases in pregnant women based on immune responses. Additionally, the possible role of Th17, alterations in some selected autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE), atopic dermatitis (AD), asthma and pemphigus during pregnancy, and possible associated mechanisms are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|