The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenerealTreponema pallidumsubspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis
| Autor: | Dongxia Wang, Madeline Y. Sutton, Hsi Liu, Amy Martin, Kristin N. Harper, Keith Levert, Paolo S. Ocampo, Bret Steiner, George J. Armelagos |
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| Rok vydání: | 2008 |
| Předmět: |
DNA
Bacterial Microbiology (medical) Sexually transmitted disease Sexual transmission Sequence analysis Molecular Sequence Data Immunology Biology Subspecies urologic and male genital diseases Microbiology Evolution Molecular Bacterial Proteins medicine Animals Humans Immunology and Allergy Treponema Amino Acid Sequence Syphilis Repeated sequence Gene Repetitive Sequences Nucleic Acid Polymorphism Genetic Base Sequence Sequence Homology Amino Acid fungi food and beverages Sequence Analysis DNA General Medicine medicine.disease biology.organism_classification Virology Infectious Diseases Rabbits |
| Zdroj: | FEMS Immunology & Medical Microbiology. 53:322-332 |
| ISSN: | 1574-695X 0928-8244 |
| Popis: | Despite the completion of the Treponema pallidum genome project, only minor genetic differences have been found between the subspecies that cause venereal syphilis (ssp. pallidum) and the nonvenereal diseases yaws (ssp. pertenue) and bejel (ssp. endemicum). In this paper, we describe sequence variation in the arp gene which allows straightforward differentiation of ssp. pallidum from the nonvenereal subspecies. We also present evidence that this region is subject to positive selection in ssp. pallidum, consistent with pressure from the immune system. Finally, the presence of multiple, but distinct, repeat motifs in both ssp. pallidum and Treponema paraluiscuniculi (the pathogen responsible for rabbit syphilis) suggests that a diverse repertoire of repeat motifs is associated with sexual transmission. This study suggests that variations in the number and sequence of repeat motifs in the arp gene have clinical, epidemiological, and evolutionary significance. |
| Databáze: | OpenAIRE |
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