Association of pre-admission statin therapy and the inflammatory response in ST elevation myocardial infarction patients
| Autor: | Natalia Kaufman, Gad Keren, Dor Ravid, Gilad Margolis, Yacov Shacham, Zach Rozenbaum, Shafik Khoury, Assi Milwidsky |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Statin medicine.drug_class Premedication Health Toxicology and Mutagenesis Inflammatory response Clinical Biochemistry Inflammation 030204 cardiovascular system & hematology Biochemistry Cohort Studies 03 medical and health sciences 0302 clinical medicine St elevation myocardial infarction Internal medicine medicine Humans cardiovascular diseases Aged biology business.industry C-reactive protein Middle Aged C-Reactive Protein 030220 oncology & carcinogenesis Cardiology biology.protein ST Elevation Myocardial Infarction Female Statin therapy Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom business |
| Zdroj: | Biomarkers. 24:17-22 |
| ISSN: | 1366-5804 1354-750X |
| DOI: | 10.1080/1354750x.2018.1460765 |
| Popis: | To demonstrate the possible association of statin therapy with C reactive protein (CRP) serial measurements in ST elevation myocardial infarction (STEMI) patients.STEMI patients between 2008 and 2016 with available CRP data from admission were divided into two groups according to pre-admission statin therapy. A second CRP measurement was noted following primary coronary intervention (within 24 h from admission). The difference between the two measurements was designated ΔCRP.The cohort consisted of 1134 patients with a median age of 61 (IQR52-70), 81% males. Patients on statins prior to admission (336/1134, 26%) were more likely to have CRP levels within normal range (≤5 mg/l) compared to patients without prior treatment, both at admission (75 vs. 24%, p = 0.004) and at 24 h (70 vs. 48%, p = 0.029). The prevalence of patients with pre-admission statin therapy decreased as ΔCRP increased (p = 0.004; n = 301). The likelihood of ΔCRP to be above 5 mg/l in patients with pre-admission statin therapy was reduced after age and gender adjustments (OR 0.54, 95% CI 0.32-0.92, p = 0.023) and in multivariate (OR 0.57, 95% CI 0.33-0.99, p = 0.048) analysis.Pre-admission statin therapy is associated with a less robust inflammatory response in STEMI patients, highlighting statin's pathophysiological importance. |
| Databáze: | OpenAIRE |
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