Presentation, management and outcomes of pediatric urogenital tuberculosis: 20 years’ experience from a tertiary center

Autor: Hardik B. Patel, Ashwin Shekar P, Dinesh Reddy, K. S. Shivakumar, Anuj Dumra, P. Satish Kumar
Rok vydání: 2021
Předmět:
Zdroj: Journal of Pediatric Urology. 17:546.e1-546.e8
ISSN: 1477-5131
DOI: 10.1016/j.jpurol.2021.04.002
Popis: Summary Background Urogenital tuberculosis (UGTB) has traditionally being a diagnosis of adulthood and is supposed to be rare in children, as it is believed that the symptoms of renal tuberculosis do not appear for 10 or more years after the primary infection. While this may be true in developed countries, where childhood pulmonary tuberculosis is a rarity nowadays. In developing countries, childhood pulmonary tuberculosis is still a major issue and hence, UGTB is not an uncommon diagnosis in younger children and adolescents in these countries. Considering this dearth of data on childhood UGTB, we retrospectively evaluated our series of children with this disease, with special emphasis on the role of surgery. Objective To analyze the clinical presentation, management strategies and outcomes of pediatric UGTB managed in a tertiary care center. Materials and methods Case records of children and adolescents ≤18 years diagnosed with UGTB during the period July 1998 to June 2018 at our center were reviewed. Clinical features, organ involvement, investigations, treatment and outcome of therapy were studied. Results There were 41 children and adolescents (M: F = 22:19) identified, with a mean age of 14.8 ± 3.9 years who fulfilled the inclusion criteria. The most common presentation was flank pain and irritative storage symptoms. Mycobacterium tuberculosis was identified on urinary examination in only 17 (41.5%) cases. Six patients were lost to follow up after initial diagnosis. A total of 45 procedures (35 primary and 10 secondary) were performed in 35 children. Initial diversion in the form of PCN and DJS were done in 11 and 12 patients respectively, of which 8 were managed with stenting alone. Surgical management was done mostly in the form of nephrectomy (15), nephrectomy along with reconstruction (5) and reconstruction only (6). On univariate analysis, factors associated with nephrectomy were poor initial function and nephrostomy as initial diversion. Overall median follow-up was 25 (IQR 15.5–74.25) months. During follow up, chronic renal failure developed in nearly 53.8% of patients who underwent major reconstruction. Conclusions Urogenital tuberculosis presents with a wide spectrum of clinical features and pathological lesions. Diagnosis is often delayed because of late presentation and many children present with cicatrization sequelae. Antitubercular drug therapy and judicious application of minimally invasive diversions and surgery (both ablative and reconstructive) achieve satisfactory results in the majority of cases. Children undergoing major surgical reconstruction in particular need to be followed up rigorously and counselled about possibility of development of renal failure. Download : Download high-res image (368KB) Download : Download full-size image Summary Figure . Flow diagram showing various primary treatment modalities used in management of childhood and adolescent Urogenital tuberculosis. Key: UGTB-Urogenital tuberculosis; PCN-Percutaneous Nephrostomy; DJS -DJ stenting; AC-Augmentation Cystoplasty; UR-ureteric reimplantation; CLT-Cystolithotripsy; I and D-Incision and Drainage; URSL-Ureterolithotripsy; PCNL-Percutaneous Nephrolithotomy.
Databáze: OpenAIRE
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