Structure of a novel sialooligosaccharide from the urine of a patient with mucolipidosis
| Autor: | Koichi Tsurumi, Masai Koseki |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
chemistry.chemical_classification
Chemical Phenomena Mucolipidosis Catabolism Chemical structure Oligosaccharides General Medicine Urine Oligosaccharide medicine.disease General Biochemistry Genetics and Molecular Biology Chemistry chemistry Biochemistry Mucolipidoses Sialic Acids medicine Lysosomal storage disease Humans Glycoside hydrolase Glycoprotein |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 124:361-366 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.124.361 |
| Popis: | A mannose-containing sialooligosaccharide has been isolated from the urine of a patient with a newly recognized mucolipidosis which showed a low liver beta-galactosidase activity and hyperglycopeptiduria. The chemical structure has been determined by glycosidase digestion, Smith degradation and permethylation studies. The following structure has been given for the oligosaccharide: NANAalpha2-6Galbeta1-4GlcNAcbeta1-2Manbeta1-3Manbeta1-4GlcNAc. This compound appears to be derived from an incomplete catabolism of glycoproteins with aspartylglucosylamine type side chains. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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