Reversible Lymphomas Associated with Epstein-Barr Virus Occurring during Methotrexate Therapy for Rheumatoid Arthritis and Dermatomyositis
| Autor: | Roger A. Warnke, Onsi W. Kamel, P K Hench, P G Montgomery, G. J. del Zoppo, B. A. Robbins, Lawrence M. Weiss, Ronald F. Dorfman, M van de Rijn |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Herpesvirus 4
Human Lymphoproliferative disorders medicine.disease_cause Dermatomyositis Virus Arthritis Rheumatoid Immune system hemic and lymphatic diseases medicine Humans Aged Aged 80 and over business.industry General Medicine medicine.disease Hodgkin Disease Epstein–Barr virus Transplantation Tumor Virus Infections Methotrexate Rheumatoid arthritis Immunology Female Lymphoma Large B-Cell Diffuse business medicine.drug |
| Zdroj: | New England Journal of Medicine. 328:1317-1321 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | An increased risk of lymphoproliferative disorders has been well documented in patients who are treated with immunosuppressive agents after organ transplantation1 and in patients with the acquired immunodeficiency syndrome2. The lymphomas that develop in immunosuppressed patients after transplantation are typically large-cell lymphomas that contain Epstein-Barr virus (EBV) and are closely linked to the level of competence of the immune system3. When treatment with immunosuppressive drugs is reduced or discontinued, these EBV-associated lymphomas may regress completely1; if the patient's immune status continues to be compromised, however, the tumor may continue to proliferate and result in death. Whether patients . . . |
| Databáze: | OpenAIRE |
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