Effect of hyperhydration on the pharmacokinetics and detection of orally administered budesonide in doping control analysis

Autor: Ioanna Athanasiadou, Miriam Mbeloug, Aristeidis Dokoumetzidis, Costas Georgakopoulos, Mohammed Al-Maadheed, Ariadni Vonaparti, Amal Saleh, Georgia Valsami
Rok vydání: 2019
Předmět:
Zdroj: Scandinavian Journal of Medicine & Science in Sports. 29:1489-1500
ISSN: 1600-0838
0905-7188
DOI: 10.1111/sms.13499
Popis: The aim of the present study was to investigate if hyperhydration could influence the excretion and subsequent detection of budesonide (BDS) and its main metabolites (6β-hydroxy-budesonide and 16α-hydroxy-prednisolone) during doping control analysis by leading to concentrations below the WADA reporting level (30 ng/mL). The influence of hyperhydration on the plasma and urinary pharmacokinetic (PK) profiles of BDS and metabolites was also examined. Seven healthy physically active non-smoking Caucasian males participated in a 15-day clinical study. BDS was administered orally at a single dose of 9 mg on Days 1, 7, and 13. Hyperhydration was applied in the morning on two consecutive days, that is, 0 and 24 hours after first fluid ingestion. Water and a commercial sports drink were used as hyperhydration agents (20 mL/kg body weight). Results showed no significant difference (P > 0.05, 95% CI) on plasma or urinary PK parameters under hyperhydration conditions for all the analytes. However, significant differences (P
Databáze: OpenAIRE
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