Treatment of severe lichen planus with mycophenolate mofetil
| Autor: | Thomas A. Luger, Stefan Beissert, Gisela Bonsmann, Thomas Schwarz, Uta Frieling |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Chemotherapy Adolescent business.industry medicine.medical_treatment Lichen Planus Complete remission Dermatology Disease Lesion formation Middle Aged Mycophenolic Acid Mycophenolate Lymphocytic Infiltrate Pathogenesis medicine Humans Female business Immunosuppressive Agents |
| Zdroj: | Journal of the American Academy of Dermatology. 49:1063-1066 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/s0190-9622(03)02111-x |
| Popis: | Lichen planus (LP) is an inflammatory skin disorder with a wide range of clinical appearances. The treatment of disseminated and especially erosive forms of LP is often difficult and disappointing. Activated T cells are important in the pathogenesis of LP as indicated by the dermal lymphocytic infiltrate leading to keratinocyte destruction and lesion formation. Similar histologic findings are present in graft-versus-host disease. Since T cells are key players in the development of both disorders and mycophenolate mofetil has been successfully introduced in the treatment of graft-versus-host disease, we have examined the therapeutic potential of this agent in 3 patients suffering from disseminated and erosive LP. Mycophenolate mofetil was well tolerated and induced complete remission in 2 patients, and substantial improvement in the third patient. |
| Databáze: | OpenAIRE |
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