Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii

Autor: Pilar Carranza-Rosales, Lucio Vera-Cabrera, José J. Fernández, Carmen A. Molina-Torres, Ezequiel Viveros-Valdez, Karla Leal-López, Sara García-Davis, Ana R. Díaz-Marrero
Jazyk: angličtina
Rok vydání: 2020
Předmět:
nontuberculous mycobacteria
Imipenem
medicine.drug_class
Antitubercular Agents
Pharmaceutical Science
Mycobacterium Infections
Nontuberculous
brominated sesquiterpenes
Drug resistance
Microbial Sensitivity Tests
Mycobacterium abscessus
Antimycobacterial
Laurencia
Microbiology
pharmacology_toxicology
Mycobacterium tuberculosis
03 medical and health sciences
Minimum inhibitory concentration
Drug Discovery
medicine
Humans
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
030304 developmental biology
antimycobacterial
0303 health sciences
biology
030306 microbiology
Communication
marine natural products
biology.organism_classification
bacterial infections and mycoses
Hydrocarbons
Brominated
tuberculosis
lcsh:Biology (General)
Nontuberculous mycobacteria
Sesquiterpenes
medicine.drug
Zdroj: Marine Drugs, Vol 18, Iss 287, p 287 (2020)
Marine Drugs
ISSN: 1660-3397
Popis: Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections.
Databáze: OpenAIRE
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