Cytogenetic findings in uterine epithelioid leiomyomas
| Autor: | Sverre Heim, Kostas Sfikas, Christos Karaiskos, Stelios Fotiou, Aliki Tserkezoglou, Georgia Bardi, Nikos Pandis |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Pathology Uterus Biology Somatic evolution in cancer Genetics medicine Humans Molecular Biology Chromosome Aberrations Uterine leiomyoma Cytogenetics Chromosome Karyotype Leiomyoma Epithelioid Anatomy Middle Aged medicine.disease female genital diseases and pregnancy complications Leiomyoma medicine.anatomical_structure In utero Karyotyping Uterine Neoplasms Female |
| Zdroj: | Cancer Genetics and Cytogenetics. 80:103-106 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(94)00167-a |
| Popis: | Epithelioid leiomyomas of the uterus, unlike ordinary leiomyomas, show substantial epithelial differentiation. No chromosome abnormalities have been reported in uterine epithelioid leiomyomas before. We analyzed short-term cultures from five such tumors and detected abnormal karyotypes in four. A del(7) (q21.2q31.2) was found in two tumors, in one as the only change and in the other as a secondary aberration acquired during clonal evolution. Rearrangement of chromosomal band 12815, another of the cytogenetic hallmarks of ordinary uterine leiomyomas, was seen in the form of a t(10;12) in one tumor. Band 17q21 was involved in structural aberrations in two cases. The data we present indicate that epithelioid leiomyomas are fundamentally similar cytogenetically, and hence presumably also pathogenetically, to the much more common smooth muscle-differentiated uterine myomas. The only differences hinted at are that epithelioid tumors may be karyotypically more complex and more often have rearrangements of 17q21. |
| Databáze: | OpenAIRE |
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