A combination treatment of folic acid, aspirin, doxycycline and progesterone for women with recurrent early pregnancy loss; hospital based study
Autor: | Ahmed M. Abbas, Alaa M. Ismail, Diaa Eldeen M. Abd Elaal, Enas I. Samy, Kamal M. Zahran, Hassan S. Kamel |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Complications of pregnancy Folic acid lcsh:QH471-489 Oligohydramnios Abortion Recurrent miscarriage 03 medical and health sciences 0302 clinical medicine Pregnancy loss Obstetrics and Gynaecology lcsh:Reproduction Medicine 030212 general & internal medicine Doxycycline lcsh:R5-920 Aspirin 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology medicine.disease Regimen Reproductive Medicine Low dose aspirin lcsh:Medicine (General) business Live birth medicine.drug |
Zdroj: | Middle East Fertility Society Journal, Vol 21, Iss 1, Pp 22-26 (2016) |
ISSN: | 1110-5690 |
Popis: | Objective: The study aims to state the effectiveness of a new combination treatment composed of folic acid, doxycycline, low dose aspirin and natural progesterone in cases of recurrent early pregnancy loss. Study design: A clinical comparative hospital-based study. Setting: Women Health Hospital – Assiut University – Egypt. Materials and methods: All patients with recurrent early pregnancy loss at 10 weeks or less attending our antenatal care unit were included. The patients were recruited over a period of 16 months and allocated into two groups. The study group received a regimen of folic acid, doxycycline, aspirin, and progesterone. The control group did not receive the previous regimen in the proposed way. The main outcome measures the live birth rate and complications of pregnancy in both groups. Results: Three hundred patients were recruited, with 150 women in each group. A high rate of live births was found in the study group (76.0%) more than the control group (59.3%). Women in the Control Group reported more complications (76.0% vs. 51.3%). These were mainly abortion (40.0% vs. 23.3%), pre-eclampsia (16.0% vs. 10.7%) and oligohydramnios (10.0% vs. 6.7%). Conclusion: The implementation of combination treatment of folic acid, doxycycline, low dose aspirin and natural progesterone resulted in a significant increase in the live birth rate, a significant reduction in miscarriages, and lower incidence of complications in patients with recurrent early pregnancy loss. |
Databáze: | OpenAIRE |
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