Repetitive Pupil Light Reflex: Potential Marker in Alzheimer's Disease?
| Autor: | Helmut Wilhelm, Isabel Wieseler, Notger G. Müller, Daniel Bittner, Matthias W. Riepe |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
genetic structures physiology [Reflex Pupillary] MAPT protein human tau Proteins Degeneration (medical) Neuropsychological Tests Audiology Reflex Pupillary Nucleus basalis physiopathology [Alzheimer Disease] Pupil Cerebrospinal fluid Alzheimer Disease medicine Humans Dementia ddc:610 Latency (engineering) Aged Tropicamide General Neuroscience diagnosis [Alzheimer Disease] General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology cerebrospinal fluid [tau Proteins] Multivariate Analysis Cholinergic methods [Photic Stimulation] sense organs Geriatrics and Gerontology Psychology Neuroscience Biomarkers Photic Stimulation medicine.drug |
| Zdroj: | Journal of Alzheimer's disease 42(4), 1469-1477 (2014). doi:10.3233/JAD-140969 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-140969 |
| Popis: | It was investigated whether alterations of the pupil's light reflex might reflect Alzheimer's disease (AD) pathology. Changes in the pupil's system might be expected due to AD pathology present in the oculomotor system of the Edinger-Westphal nucleus, and a cholinergic deficit caused by degeneration of the nucleus basalis Meynert. A rather new method of repetitive light stimulation was applied assessing variations in pupil size, latency, and amplitude over time. We analyzed 44 healthy controls, 42 subjects with mild cognitive impairment (MCI), and 66 AD patients. AD and MCI showed a less pronounced pupil size decrease and amplitude increase over time than controls. A higher MMSE was associated with a higher increase of relative amplitude and greater decrease of latency in AD and MCI, and absolute amplitude increase in AD alone. Pupil size increase correlated with cerebrospinal fluid markers in AD. Summarized pupil light reflex is not stable under repetitive stimulation, but changes systematically and less pronounced in AD and MCI. Thus repetitive stimulation of the pupil's response potentially indicates AD pathology. |
| Databáze: | OpenAIRE |
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