Lung cancer in renal transplant recipients: A case-control study
| Autor: | Christophe Legendre, Elisabeth Longchampt, Claire Rousseau-Gazaniol, Leila Tricot, Gaëlle Pellé, Frank Martinez, Michel Delahousse, Henri Kreis, Dany Anglicheau, Pierre Bonnette, Philippe Puyo, Patricia Moisson, François Mellot, Séverine Fraboulet, Louis-Jean Couderc, Sylvie Friard, Alain Chapelier, Emilie Catherinot, Raphael Borie, Abdul Monem Hamid, Marie-Ange Massiani, Leila Zemoura, Edouard Sage, Hélène Doubre |
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| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Population Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine education Lung cancer Kidney transplantation Aged Neoplasm Staging Retrospective Studies Aged 80 and over education.field_of_study business.industry Incidence (epidemiology) Incidence Case-control study Cancer Retrospective cohort study Middle Aged medicine.disease Combined Modality Therapy Kidney Transplantation Transplant Recipients Transplantation 030220 oncology & carcinogenesis Case-Control Studies Population Surveillance Female business |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 111 |
| ISSN: | 1872-8332 |
| Popis: | Introduction Solid organ transplant patients are at heightened risk of several cancers compared to the general population. Secondary to a higher number of procedures and better survival after transplantation, cancer is a rising health concern in this situation. Limited data exist for lung cancer (LC) after renal transplantation. We report here the most important series of renal transplant recipients with lung cancer. Methods Retrospective study of all cases of LC diagnosed in three French Renal Transplant Units from 2003 to 2012. A control group consisted of non-transplant patients with LC matched with the cases for age ( 65 years), gender and diagnosis date. We recruited two controls for each case. Results Thirty patients (median age 60 years; range 29–85; male/female ratio 80/20%) with LC were analysed. LC incidence was 1.89/1000 person-years over the period 2008–2012. All patients were former or active smokers (median 30 pack-years). Transplanted patients had significantly more comorbidities, mainly cardiovascular disease. The median interval of time from kidney transplantation (KT) to diagnosis of LC was 7 years (range 0.5–47 years). LC was incidentally diagnosed in 40%. Most patients (70%) had advanced LC (stage III or IV) disease. Stage of LC at diagnosis was similar in cases and controls. Surgery and chemotherapy were proposed to the same proportion of patients. In cases, mortality was cancer related in 87% and median survival time after diagnosis was 24 months. Survival was not significantly different between the 2 groups. Conclusion Despite frequent medical and radiological examinations, diagnosis of LC is usually made at an advanced stage and the overall prognosis remains poor. |
| Databáze: | OpenAIRE |
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