Saponins as modulators of nuclear receptors
| Autor: | Shuning Zhong, Tiehua Zhang, Jie Zhang, Tiezhu Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
030309 nutrition & dietetics
medicine.medical_treatment Receptors Cytoplasmic and Nuclear Peroxisome proliferator-activated receptor Pharmacology Ligands Industrial and Manufacturing Engineering 03 medical and health sciences 0404 agricultural biotechnology medicine Receptor Liver X receptor chemistry.chemical_classification 0303 health sciences Pregnane X receptor Chemistry Biological activity 04 agricultural and veterinary sciences General Medicine Saponins 040401 food science Steroid hormone Nuclear receptor Carrier Proteins Food Science Hormone |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 60:94-107 |
| ISSN: | 1549-7852 1040-8398 |
| DOI: | 10.1080/10408398.2018.1514580 |
| Popis: | As plant-derived natural products, saponins have been widely applied for the dietary modification of metabolic syndrome. However, the underlying mechanisms of their preventive and therapeutic effects are still largely unclear. Nuclear receptors have been identified as potential pharmaceutical targets for treating various types of metabolic disorders. With similar structure to endogenous hormones, several saponins may serve as selective ligands for nuclear receptors. Recently, a series of saponins are proved to exert their physiological activities through binding to nuclear receptors. This review summarizes the biological and pharmacological activities of typical saponins mediated by some of the most well described nuclear receptors, including the classical steroid hormone receptors (ER, GR, MR, and AR) and the adopted orphan receptors (PPAR, LXR, FXR, and PXR). |
| Databáze: | OpenAIRE |
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