Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes

Autor: Kirstine N. Bojsen-Møller, Sten Madsbad, Tang Cam Phung Pham, Jørgen F. P. Wojtaszewski, Erik A. Richter, Lykke Sylow
Rok vydání: 2020
Předmět:
Blood Glucose
Male
Follistatin
Time Factors
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Activin Receptors
Type II
Biopsy
Medicine (miscellaneous)
Adipose tissue
Type 2 diabetes
0302 clinical medicine
030212 general & internal medicine
Inhibin-beta Subunits
Nutrition and Dietetics
biology
Muscles
Middle Aged
Roux-en-Y anastomosis
Activins
Obesity
Morbid
medicine.anatomical_structure
Adipose Tissue
Female
Signal transduction
hormones
hormone substitutes
and hormone antagonists
Signal Transduction
Adult
endocrine system
medicine.medical_specialty
Gastric Bypass
030209 endocrinology & metabolism
Glycemic Control
03 medical and health sciences
Downregulation and upregulation
Internal medicine
medicine
Humans
business.industry
nutritional and metabolic diseases
Skeletal muscle
medicine.disease
Obesity
Endocrinology
Glucose
Diabetes Mellitus
Type 2
biology.protein
business
human activities
Follow-Up Studies
Zdroj: International journal of obesity (2005). 45(2)
ISSN: 1476-5497
Popis: Roux-en-Y gastric bypass (RYGB) surgery is a therapeutic intervention for morbid obesity and type 2 diabetes (T2D) that improves metabolic regulation. Follistatin (Fst) could be implicated in improved glycemia as it is highly regulated by RYGB. However, it is unknown if metabolic status, such as T2D, alters the Fst response to RYGB. In addition, the effect of RYGB on the Fst target, activin A, is unknown in individuals with obesity and T2D, but is needed to interpret the functional effects of altering Fst. Finally, whether Fst-regulated intracellular signaling contributes to beneficial effects of RYGB is undetermined. Circulating Fst and activin A were measured before, 1 week, and 1 year after RYGB surgery in a total of 20 individuals with obesity, 10 with normoglycemia (NGT) and 10 with preoperative T2D. Intracellular signaling downstream of the Activin receptor type IIB (ActRIIB) signaling pathway was analyzed in skeletal muscle and adipose tissue. The doubling in circulating Fst observed in subjects with NGT 1-week and 1-year post surgery was absent in T2D. After 1 week, RYGB reduced activin A by 27% (p
Databáze: OpenAIRE
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