Galectin-3 and β-trace protein concentrations are higher in clinically unaffected patients with Fabry disease
| Autor: | Diana Hernández-Romero, Gregory Y.H. Lip, Jessica Sánchez-Quiñones, Juan Antonio Vílchez, José Miguel Rivera-Caravaca, Francisco Marín, Gonzalo de la Morena, Vicente Climent |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cardiac fibrosis Galectin 3 lcsh:Medicine Gastroenterology Prognostic markers 0302 clinical medicine Risk Factors Natriuretic Peptide Brain Natriuretic peptide Medicine Outpatient clinic lcsh:Science Multidisciplinary Blood Proteins Middle Aged Prognosis Healthy Volunteers Lipocalins Intramolecular Oxidoreductases Cardiovascular diseases Galectin-3 Female medicine.symptom Adult medicine.medical_specialty medicine.drug_class Galectins Renal function Inflammation Predictive markers Article Young Adult 03 medical and health sciences Troponin T Internal medicine Humans Interleukin-6 business.industry β trace protein lcsh:R Diagnostic markers medicine.disease Fabry disease Peptide Fragments 030104 developmental biology Spain alpha-Galactosidase Mutation Fabry Disease lcsh:Q business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Hernández-Romero, D, Sánchez-Quiñones, J, Vílchez, J A, Rivera-Caravaca, J M, de la Morena, G, Lip, G Y H, Climent, V & Marín, F 2019, ' Galectin-3 and β-trace protein concentrations are higher in clinically unaffected patients with Fabry disease ', Scientific Reports, vol. 9, no. 1, 6235 . https://doi.org/10.1038/s41598-019-42727-4 Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) Scientific Reports |
| Popis: | Current therapies have not shown benefit in organ damage reversal in Fabry disease (FD), but biomarkers could help risk stratification and prognosis. We investigated if several biomarkers of cardiac fibrosis, cardiac wall stress, myocardial injury, renal function and inflammation, are associated with early cardiac affectation in FD patients. We included FD patients from four cardiology outpatient clinics of southeastern Spain. At inclusion, Galectin-3 (Gal-3), N-terminal proB-type natriuretic peptide, high sensitivity troponin T (hsTnT), β-trace protein (BTP) and interleukin-6 concentrations were measured. The relation of biomarkers concentrations with clinical features, cardiac involvement and organ affectation according to the Mainz Severity Score Index (MSSI) was investigated. 44 FD patients (n = 21 affected and n = 23 unaffected) were compared to age and sex-respectively matched healthy controls. Significant differences in biomarkers’ concentration between FD groups were observed. Importantly, Gal-3 and BTP levels were higher in unaffected patients when compared with age and sex-matched healthy controls (both p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|