Corneal Collagen Cross-Linking with Hypoosmolar Riboflavin Solution in Keratoconic Corneas
| Autor: | Lihua Wang, Zhaoshan Fan, Xiangchen Tao, Guoying Mu, Yong Zhang, Shaofeng Gu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Keratoconus Distance visual acuity Visual acuity Article Subject genetic structures Corneal Pachymetry Riboflavin Corneal collagen cross-linking Visual Acuity lcsh:Medicine Cell Count General Biochemistry Genetics and Molecular Biology Cornea Ophthalmology medicine Humans Corneal pachymetry Dioptre General Immunology and Microbiology medicine.diagnostic_test business.industry lcsh:R Epithelium Corneal Endothelial Cells General Medicine medicine.disease eye diseases Surgery Solutions medicine.anatomical_structure Cross-Linking Reagents Hypotonic Solutions Clinical Study Female sense organs Collagen medicine.symptom business |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Purpose. To report the 12-month outcomes of corneal collagen cross-linking (CXL) with a hypoosmolar riboflavin and ultraviolet-A (UVA) irradiation in thin corneas.Methods. Eight eyes underwent CXL using a hypoosmolar riboflavin solution after epithelial removal. The corrected distance visual acuity (CDVA), manifest refraction, the mean thinnest corneal thickness (MTCT), and the endothelial cell density (ECD) were evaluated before and 6 and 12 months after CXL.Results. The MTCT was 413.9 ± 12.4 μm before treatment and reduced to 381.1 ± 7.3 μm after the removal of the epithelium. After CXL, the thickness decreased to 410.3 ± 14.5 μm at the last follow-up. Before treatment, the meanK-value of the apex of the keratoconus corneas was 58.7 ± 3.5 diopters and slightly decreased (57.7 ± 4.9 diopters) at 12 months. The mean CDVA was 0.54 ± 0.23 logarithm of the minimal angle of resolution before treatment and increased to 0.51 ± 0.21 logarithm at the last follow-up. The ECD was 2731.4 ± 191.8 cells/mm2before treatment and was 2733.4 ± 222.6 cells/mm2at 12 months after treatment.Conclusions. CXL with a hypoosmolar riboflavin in thin corneas seems to be a promising method for keratoconic eyes with the mean thinnest corneal thickness less than 400 μm without epithelium. |
| Databáze: | OpenAIRE |
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