The osmotic demyelination syndrome: the resilience of thalamic neurons is verified with transmission electron microscopy
| Autor: | Jean Pierre Brion, Jacques Gilloteaux, Joanna Bouchat, Charles Nicaise |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine restoration Nucleolus Thalamus nucieus Pathology and Forensic Medicine Mice 03 medical and health sciences Myelin 0302 clinical medicine Microscopy Electron Transmission Structural Biology thalamus Parenchyma Neuropil medicine Animals nucleolus Murine Neurons murine Histologie Chemistry nucleus Médecine pathologie humaine cell body Syndrome Sciences bio-médicales et agricoles ultrastructure neuron Cell biology Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure nervous system 030220 oncology & carcinogenesis Ultrastructure Neuron Nucleus osmotic demyelination syndrome Demyelinating Diseases Hyponatremia cell injury |
| Zdroj: | Ultrastructural pathology, 44 (4-6 GILLOTEAUX, J, Bouchat, J, Brion, J P & Nicaise, C 2020, ' The osmotic demyelination syndrome : the resilience of thalamic neurons is verified with transmission electron microscopy ', Ultrastructural Pathology, vol. 44, no. 4-6, pp. 450-480 . https://doi.org/10.1080/01913123.2020.1853865 |
| DOI: | 10.1080/01913123.2020.1853865 |
| Popis: | The development of a murine model of osmotic demyelinating syndrome (ODS) allowed to study changes incurred in extrapontine zones of the CNS and featured neuron and glial cell changes in the relay thalamic ventral posterolateral (VPL) and ventral posteromedial (VPM) nuclei before, during and after ODS induction, and characterized without immune response. There, the neuron Wallerian-type deteriorations were verified with fine structure modifications of the neuron cell body, including some nucleus topology and its nucleolus changes. Morphologic analyses showed a transient stoppage of transcriptional activities while myelinated axons in the surrounding neuropil incurred diverse damages, previously reported. Even though the regional thalamus myelin deterioration was clearly recognized with light microscopy 248 h after osmotic recovery of ODS, ultrastructure analyses demonstrated that, at that time, the same damaged parenchyma regions contained nerve cell bodies that have already reactivated nucleus transcriptions and neuroplasm translations because peculiar accumulations of fibro-granular materials, similar to those detected in restored ODS astrocytes, were revealed in these restructuring nerve cell bodies. Their aspects suggested to be accumulations of ribonucleoproteins. The findings suggested that progressive neural function's recovery in the murine model could imitate some aspects of human ODS recovery cases. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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