Inkjet printing of insulin microneedles for transdermal delivery
| Autor: | Dimitrios A. Lamprou, David Mallinson, Nicolaos Scoutaris, Dennis Douroumis, Steven A. Ross |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
Materials science Microinjections Polymers Swine medicine.medical_treatment Pharmaceutical Science Nanotechnology In Vitro Techniques Administration Cutaneous Microscopy Atomic Force Gelatin chemistry.chemical_compound food Drug Delivery Systems Drug Stability medicine Animals Hypoglycemic Agents Insulin Technology Pharmaceutical Inkjet printing Transdermal Skin chemistry.chemical_classification Atomic force microscopy Polymer Equipment Design Trehalose Drug Liberation Chemical engineering chemistry Homogeneous Needles Microscopy Electron Scanning |
| Zdroj: | Drug delivery and translational research. 5(4) |
| ISSN: | 2190-3948 2190-393X |
| Popis: | Inkjet printing technology was used to apply insulin polymeric layers on metal microneedles for transdermal delivery. A range of various polymers such as gelatin (GLN), polyvinyl caprolactame-polyvinyl acetate-polyethylene glycol (SOL), poly(2-ethyl-2-oxazoline) (POX) and trehalose (THL) were assessed for their capacity to form thin uniform and homogeneous layers that preserve insulin intact. Atomic force microscopy (AFM) showed homogeneous insulin–polymer layers without any phase separation while SOL demonstrated the best performance. Circular discroism (CD) analysis of rehydrated films showed that insulin’s alpha helices and β–sheet were well preserved for THL and SOL. In contrast, GLN and POX insulin layers revealed small band shifts indicating possible conformational changes. Insulin release in Franz diffusion cells from MNs inserted into porcine skin showed rapid release rates for POX and GLN within the first 20 min. Inkjet printing was proved an effective approach for transdermal delivery of insulin in solid state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink