Adenosine Inhibition of Lymphocyte-Mediated Cytolysis: Possible Role of Cyclic Adenosine Monophosphate
| Autor: | Li-Chiang Chu, Gerald Wolberg, Marvin Winston, Kay Hiemstra, Thomas P. Zimmerman |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adenosine
chemistry.chemical_compound Adenosine A1 receptor Adenosine deaminase Cyclic AMP medicine Animals Cyclic adenosine monophosphate Lymphocytes Immunity Cellular Leukemia Experimental Multidisciplinary Dose-Response Relationship Drug biology AMP deaminase Purinergic signalling Cytotoxicity Tests Immunologic Adenosine A3 receptor medicine.disease Molecular biology Chromium Radioisotopes Adenosine deaminase deficiency chemistry Biochemistry biology.protein Immunosuppressive Agents medicine.drug |
| Zdroj: | Science. 187:957-959 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.167434 |
| Popis: | The in vitro destruction of tumor cells by specifically sensitized mouse lymphocytes was inhibited by adenosine; this inhibition was markedly potentiated by the presence of an inhibitor of adenosine deaminase. The inhibition of cytolysis by adenosine was accompanied by a rapid elevation in lymphocytic adenosine 3',5'-monophosphate (cyclic AMP) concentrations. Both the inhibition of cytolysis and the elevation of cyclic AMP were reversed by prolonged incubation of the lymphocytes in the presence of adenosine or, more rapidly, by removal of the adenosine. Low concentrations of adenosine also caused an elevation of cyclic AMP in human lymphocytes, and this effect of adenosine may contribute to the lack of immune response associated with adenosine deaminase deficiency. |
| Databáze: | OpenAIRE |
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