N-acetylcysteine decreases dopamine transporter availability in the non-lesioned striatum of the 6-OHDA hemiparkinsonian rat

Autor:	Ana Virel, Jarkko Johansson, Jan Axelsson, Madelene Ericsson, Rutger Laterveer, Mattias Ögren, Greger Orädd, Susanna Jakobson Mo, Sara af Bjerkén
Rok vydání:	2022
Předmět:	Dopamine Plasma Membrane Transport Proteins Nortropanes General Neuroscience Parkinson Disease Antioxidants Corpus Striatum Acetylcysteine Rats Rats Sprague-Dawley Positron-Emission Tomography Animals Female Radiopharmaceuticals Oxidopamine
Zdroj:	Neuroscience Letters. 770:136420
ISSN:	0304-3940
DOI:	10.1016/j.neulet.2021.136420
Popis:	This study aimed to explore the beneficial effects of the antioxidant N-acetylcysteine (NAC) on the degenerated dopamine system. The short- and long-term regulatory mechanisms of NAC on the 6-OHDA hemiparkinsonian rat model were longitudinally investigated by performing positron emission tomography (PET) imaging using the specific dopamine transporter (DAT) radioligand [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b359ddbe7d836a0c2534481609749074 https://doi.org/10.1016/j.neulet.2021.136420 Zobrazit plný text záznamu Full Text from ScienceDirect