Comorbid disorders in posttraumatic and post-success epilepsy. Possibilities of therapy

Autor: T. O. Andreeva, I. O. Ostapenko, A. O. Kaptalan, O. M. Stoyanov, S. M. Oliinyk
Rok vydání: 2021
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 11, Iss 3, Pp 113-120 (2021)
ISSN: 2391-8306
Popis: Kaptalan A. O., Andreeva T. O., Stoyanov O. M., Ostapenko I. O., Oliinyk S. M. Comorbid disorders in posttraumatic and post-success epilepsy. Possibilities of therapy. Journal of Education, Health and Sport. 2021;11(03): 113-120. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.03.012 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.03.012 https://zenodo.org/record/4651708 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.02.2021. Revised: 26.02.2021. Accepted: 31.03.2021. COMORBID DISORDERS IN POSTTRAUMATIC AND POST-SUCCESS EPILEPSY. POSSIBILITIES OF THERAPY A. O. Kaptalan, T. O. Andreeva, O. M. Stoyanov⃰, I. O. Ostapenko⃰, S. M. Oliinyk⃰ Ukrainian Research Institute of Transport Medicine, Odessa ⃰Odessa National Medical University Abstract In the article, the authors substantiate the methods of treatment of the most common cause of symptomatic epilepsy in adults, namely traumatic and ischemic. The complexity of treatment is the need to take into account the location and magnitude of brain damage, the severity of the pathological process, risk factors for the most symptomatic epilepsy, the presence of comorbid pathology. Also, the large number of side effects from taking antiepileptic drugs, encourages the discovery of new treatments. A method of treating post-traumatic epilepsy (PTE), in which, in addition to standard anticonvulsant therapy, other drugs were prescribed, such as: ethylmethylhydroxypyridine succinate, nootropic heptapeptide ACTH 4-10, Magnerot, ethylmethylhydroxypyridine succinate, Semax 0.1% solution. Fifteen patients with PTE and 19 patients with post-stroke epilepsy (PIE) were examined. In the process of examination of patients with PTE, the main neurological syndromes that accompany epilepsy are identified and are often combined with each other. At PIE in the anamnesis all patients had various cardiovascular pathology: cerebral atherosclerosis, arterial hypertension, diabetes mellitus, ischemic heart disease, etc. During treatment, in addition to controlling seizures, the number of complaints of cephalgia decreased, the signs of clinical depression and subjective experiences decreased. Positive changes in bioelectrogenesishave been registered. The state of short-term and long-term memory, stability of attention has improved. A positive effect was obtained from the treatment of seizures and comorbid pathology. The alternating effect of the proposed drugs on the background of anticonvulsant therapy leads to a significant reduction in the number and duration of epileptic seizures. Key words: symptomatic epilepsy; comorbid diseases; traumatic brain injury; stroke; treatment
Databáze: OpenAIRE
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