Behçet's disease: activated T lymphocytes in retinal perivasculitis
| Autor: | Sl Lightman, Dg Charteris, C Champ, A R Rosenthal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Vasculitis Pathology medicine.medical_specialty T-Lymphocytes Optic Disk Optic disk Behcet's disease Lymphocyte Activation Cellular and Molecular Neuroscience chemistry.chemical_compound medicine Humans Retina Retinal pigment epithelium Retinal vasculitis business.industry Behcet Syndrome Retinal Vessels Retinal medicine.disease eye diseases Sensory Systems Ophthalmology medicine.anatomical_structure chemistry Optic nerve business Research Article |
| Popis: | A 38-year-old man who died from systemic Behcet's disease had previously suffered from severe, recurrent bilateral retinal vasculitis, and anterior uveitis for 10 years. Immunopathological examination of the eyes postmortem revealed marked hyaline thickening of the retinal and optic nerve vessels. The vessels had an intramural and perivascular infiltrate of T lymphocytes which stained positively for CD4 and IL2 receptor surface markers. Small numbers of cells in the optic nerve head, retinal vascular endothelium, and retinal pigment epithelium were HLA DR positive. |
| Databáze: | OpenAIRE |
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