Inter-ictal brain SPET in frontal epilepsy
| Autor: | E. Landre, M. O. Habert, May Ghossoub, Baris Turak, S. Askienazy, C. Munari, P. Vera, B. Devaux, P. Chauvel, O. Missir, F. Chassoux |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Adolescent Epilepsy Frontal Lobe Electroencephalography Central nervous system disease Lesion Epilepsy medicine Humans Radiology Nuclear Medicine and imaging Ictal Age of Onset Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Brain Magnetic resonance imaging General Medicine medicine.disease Frontal lobe Female medicine.symptom Nuclear medicine business Perfusion |
| Zdroj: | Nuclear Medicine Communications. 16:591-598 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-199507000-00011 |
| Popis: | Summary Single photon emission tomography (SPET) imaging holds promise for localization of the site of extratemporal seizures, but limited data currently exist; in particular, correlations with stereo-electroencephalography (S-EEG) have not been made. Ten patients aged 14–44 years (mean 25 years) with a proven frontal or central epilepsy by S-EEG and post-surgical follow-up were studied retrospectively: 7 patients had frontal cortectomy and one patient had a callosotomy for bifrontal epilepsy. All patients underwent clinical, inter-ictal and ictal video-EEG, computed tomography scan and/or magnetic resonance imaging, SPET and S-EEG examinations. SPET was performed inter-ictally, while on usual epileptic medications, using 99Tcm-HMPAO (n=4) or 123I-IMP (n=6) as the perfusion tracer. The SPET images were evaluated independently by two observers, blind to any data other than the diagnosis of frontal or central epilepsy. Localization of inter-ictal SPET hypoperfusion was compared with the epileptogenic (EZ), irritative (IZ) and lesional (LZ) zones, as defined by S-EEG. Six patients showed structural frontal abnormalities. One patient had normal SPET and one had a contralateral hypoperfusion. Therefore, concordance of sides was found in 8 of 10 patients (including one with bilateral SPET and S-EEG abnormalities). The hypoperfusion was equal to or larger than the EZ + IZ + LZ in 6 patients (5 had a frontal lesion). SPET hypoperfusion was smaller than the EZ in one patient, and different from the EZ, IZ and LZ in two patients. Although this was a retrospective study, it provides qualitative data regarding the significance of inter-ictal SPET abnormalities in frontal or central epilepsy. The inter-ictal SPET hypoperfusion did not provide a precise definition of the epileptogenic focus; it was often larger than the EZ, including the IZ and LZ. This result indicates frequent widespread dysfunction in the brain of patients with frontal lobe epilepsy. |
| Databáze: | OpenAIRE |
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