Reduced serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes
| Autor: | Yaya Lv, Yonghong Li, Jing Liu, Guanghao Xia, Suhong Wei, Zubang Zhou, Juxiang Liu, Lijuan Zhang, Jinxing Quan, Guohua Sun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Clinical Biochemistry Type 2 diabetes 030204 cardiovascular system & hematology Biochemistry Cohort Studies Diabetes Complications 03 medical and health sciences 0302 clinical medicine Risk Factors Epidermal growth factor Internal medicine medicine Humans In patient Subclinical infection Glycated Hemoglobin business.industry Growth factor Biochemistry (medical) nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Atherosclerosis Milk Proteins medicine.disease C-Reactive Protein 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Antigens Surface Microvessels Biomarker (medicine) Hemoglobin business Biomarkers |
| Zdroj: | Clinica Chimica Acta. 466:201-206 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2017.01.013 |
| Popis: | Background The association between serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations and vascular complications in T2DM remains unclear. Methods A total of 149 patients with T2DM were included. The serum concentrations of MFG-E8, glycosylated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured. Results There was no significant difference in serum MFG-E8 concentrations between the T2DM group and the T2DM with subclinical atherosclerosis (AS) group (615.49 ± 143.54 vs. 596.22 ± 79.46 ng/ml, P = 0.365), while the serum concentrations of MFG-E8 in the T2DM with microvascular complications group (446.70 ± 61.53 ng/ml) and the T2DM with subclinical AS and microvascular complications group (200.87 ± 38.86 ng/ml) were significantly lower than those in the T2DM group (P = 0.000 for both). In addition, hs-CRP and HbAlc concentrations were independently associated with serum MFG-E8 concentrations (P = 0.024 and P = 0.01, respectively), and low serum MFG-E8 concentrations were significantly associated with an increased risk of microvascular complications in T2DM patients. Conclusions Serum concentrations of MFG-E8 were negatively associated with the risk of microvascular complications in patients with T2DM. Thus, it might be a potential candidate biomarker for diabetic microvascular complications. |
| Databáze: | OpenAIRE |
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