Nongenetic reprogramming of a fungal highly reducing polyketide synthase
| Autor: | Russell J. Cox, Zahida Wasil, Laura M. Halo, Andy M. Bailey, Jack R. Davison, Craig P. Butts, Thomas J. Simpson, Colin M. Lazarus, Ahmed A. Yakasai |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular biology Chemistry Pyridones Molecular Conformation General Chemistry Biochemistry Catalysis Fatty acid synthase chemistry.chemical_compound Colloid and Surface Chemistry Biosynthesis Polyketide synthase Gene cluster biology.protein Gene silencing Epigenetics Gene Silencing RNA Messenger Beauveria Reprogramming Gene Oxidation-Reduction Polyketide Synthases |
| Zdroj: | Journal of the American Chemical Society. 133(28) |
| ISSN: | 1520-5126 |
| Popis: | The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase. |
| Databáze: | OpenAIRE |
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