Synaptic vesicle protein 2: A multi-faceted regulator of secretion
| Autor: | Daniele Marcotulli, Kristine Ciruelas, Sandra M. Bajjalieh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Regulator Nerve Tissue Proteins Biology Synaptic vesicle Article Exocytosis 03 medical and health sciences 0302 clinical medicine Animals Humans Secretion Molecular Targeted Therapy Cognitive decline Receptor Membrane Glycoproteins Cell Biology Secretory Vesicle Cell biology 030104 developmental biology Calcium Synaptic Vesicles Nervous System Diseases 030217 neurology & neurosurgery Function (biology) Developmental Biology |
| Zdroj: | Semin Cell Dev Biol |
| ISSN: | 1084-9521 |
| Popis: | The twin goals of determining how neural secretion is unique and how proteins in the presynaptic terminal can be targeted in the treatment of neurological disorders are both met in the study of SV2. Unlike the machinery of vesicle fusion, SV2 is unique to regulated secretion and has no functional homolog in the vesicles that mediate membrane trafficking at other cellular locations. SV2 is, to date, the only synaptic vesicle protein that is a viable therapeutic target in the treatment of nervous system diseases. This may be linked to the fact that its function(s) are limited to quiescent synapses. By playing an essential role in regulating initial release probability, SV2 action has special relevance to neural network synchrony. Given the role of aberrant excitability in numerous neurological disorders, the relevance of SV2 to drug development will likely only grow. |
| Databáze: | OpenAIRE |
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