GnRH neurogenesis depends on embryonic pheromone receptor expression
| Autor: | Thomas Braun, Thomas Schmid, Ulrich Boehm |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male endocrine system Vomeronasal organ Receptor expression Neurogenesis Hypothalamus 030209 endocrinology & metabolism Biology Biochemistry Amygdala Pheromones Gonadotropin-Releasing Hormone 03 medical and health sciences Vomeronasal receptor Mice 0302 clinical medicine Endocrinology Pregnancy medicine Basic Helix-Loop-Helix Transcription Factors Animals Molecular Biology Cells Cultured Mice Knockout Neurons Chemotactic Factors Gene Expression Regulation Developmental Embryo Mammalian Receptors Pheromone Cell biology 030104 developmental biology medicine.anatomical_structure nervous system Pheromone Nasal placode Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecular and cellular endocrinology. 518 |
| ISSN: | 1872-8057 |
| Popis: | Gonadotropin-releasing hormone (GnRH) neurons control mammalian reproduction and migrate from their birthplace in the nasal placode to the hypothalamus during development. Despite much work on the origin and migration of GnRH neurons, the processes that control GnRH lineage formation are not fully understood. Here, we demonstrate that Nhlh genes control vomeronasal receptor expression in the developing murine olfactory placode associated with the generation of the first GnRH neurons at embryonic days (E)10-12. Inactivation of s2-microglobulin (s2-m), which selectively affects surface expression of V2Rs, dramatically decreased the number of GnRH neurons in the Nhlh2 mutant background, preventing rescue of fertility in female Nhlh2 mutant mice by male pheromones. In addition, we show that GnRH neurons generated after E12 fail to establish synaptic connections to the vomeronasal amygdala, suggesting the existence of functionally specialized subpopulations of GnRH neurons, which process pheromonal information. |
| Databáze: | OpenAIRE |
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