Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and pancreatic cancer incidence and mortality: A prospective cohort study

Autor: Qu-Jin Li, Shan Liu, Guo-Chao Zhong, Fa-Bao Hao, Zhi‐Qing Zhang, You-Qi-Le Wu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Cancer Research
Time Factors
Population
pancreatic cancer
Risk Assessment
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Risk Factors
Pancreatic cancer
Cause of Death
WCRF/AICR
medicine
Humans
Radiology
Nuclear Medicine and imaging
Healthy Lifestyle
Prospective Studies
Prospective cohort study
education
Exercise
Aged
Original Research
education.field_of_study
Cancer prevention
business.industry
Incidence (epidemiology)
Cancer
Middle Aged
Protective Factors
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
mortality
Confidence interval
United States
Pancreatic Neoplasms
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cohort
Cancer research
incidence
Female
Smoking Cessation
Diet
Healthy
business
Risk Reduction Behavior
Cancer Prevention
Zdroj: Cancer Medicine, Vol 9, Iss 18, Pp 6843-6853 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Background Whether adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations is associated with a reduced risk of pancreatic cancer remains controversial. Additionally, no study has investigated this association in the US population. Hence, we investigated the association of adherence to the 2018 WCRF/AICR cancer prevention recommendations with pancreatic cancer incidence and mortality in a US population. Methods A population‐based cohort of 95 962 participants was identified. A score incorporating eight WCRF/AICR components was constructed to reflect adherence to the WCRF/AICR guidelines, with higher scores representing greater adherence to the guidelines. Cox and competing risk regression were used to calculate risk estimates for pancreatic cancer incidence and mortality, respectively. Restricted cubic spline functions were used to test nonlinearity. Results In the fully adjusted model, higher overall WCRF/AICR scores were shown to be associated with lower risks of developing pancreatic cancer (hazard ratiotertile 3 vs 1:0.67; 95% confidence interval: 0.49, 0.90; P trend = .0099) and mortality due to this cancer (subdistribution hazard ratiotertile 3 vs 1 0.65; 95% confidence interval: 0.47, 0.89; P trend = .0108) in a linear dose–response manner (all P nonlinearity > .05). The component “be physically active” was shown to be a key contributor to the observed associations. No association of the diet‐specific WCRF/AICR score with pancreatic incidence and mortality was found. Conclusions Adherence to the 2018 WCRF/AICR guidelines, especially “be physically active,” confers reduced risks of pancreatic cancer incidence and mortality in the US population; however, adherence to dietary components alone does not confer such beneficial effects.
In this prospective study of 95962 American adults, we found that greater adherence to the 2018 WCRF/AICR recommendations was associated with lower risks of pancreatic cancer incidence and mortality. However, such beneficial effects were not found for adherence to diet‐specific recommendations alone.Importantly, the component “be physically active” was found to be a key driver of the observed associations.
Databáze: OpenAIRE
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