A 1-year toxicity study in dogs is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides
| Autor: | Ivana Fegert, Phil Botham, Werner Bomann, Bernhard Stahl, Bennard van Ravenzwaay, Horst Spielmann, Werner Kobel, Karin S. Bentley, Richard Lewis, Richard Billington |
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| Rok vydání: | 2009 |
| Předmět: |
Time Factors
International Cooperation Legislation Toxicology Multiple dose Biosafety Dogs Species Specificity Environmental protection Environmental health Toxicity Tests Animals Humans media_common.cataloged_instance Medicine European Union Pesticides United States Environmental Protection Agency European union media_common Weight of evidence business.industry Pesticide United States Toxicity business Risk assessment |
| Zdroj: | Critical Reviews in Toxicology. 40:1-15 |
| ISSN: | 1547-6898 1040-8444 |
| DOI: | 10.3109/10408440903300098 |
| Popis: | A review of publications on pesticides assessing the need for 1-year toxicity studies in dogs was performed. Four key peer-reviewed papers with different approaches investigated the value of a 1-year dog study in addition to a 3-month study. Despite different databases and approaches, each concluded with the recommendation to limit the testing of pesticides in dogs to a duration of 3 months. The combined weight of evidence presented in this review reinforces these independent conclusions. Therefore, the routine inclusion of a 1-year dog study as a mandated regulatory requirement for the safety assessment of pesticides is no longer justifiable and a globally harmonized approach should be taken to match the latest legislation of the European Union and the US EPA. |
| Databáze: | OpenAIRE |
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