Ultrastructural analysis of changes in myocardial blood microvessels in severe burn shock
| Autor: | Sergey V. Savchenko, Natalia G. Oshchepkova, Nataliya P. Bgatova, Yulia S. Taskaeva, Evgeny V. Kuznetsov, Vladimir P. Novoselov, Аndrey Yu. Letyagin |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Burn injury Endothelium microcirculatory bed business.industry High mortality burn shock ultrastructure Exocytosis medicine.anatomical_structure endotheliocyte Shock (circulatory) myocardium cardiovascular system Ultrastructure medicine Medicine medicine.symptom business Intracellular Burn shock |
| Zdroj: | Сибирский научный медицинский журнал, Vol 41, Iss 3, Pp 71-77 (2021) |
| ISSN: | 2410-2520 2410-2512 |
| Popis: | Burn injury is an important medical problem, as it is accompanied by high mortality rates in burn shock. Aim of the study was to conduct an ultrastructural stereological analysis of changes in the blood microvessels of the left ventricular myocardium in burn shock.Material and methods. Myocardial samples during the early section were collected 2 hours after the detection of biological death in the victims from severe burn shock (3 men and 2 women); age group 32-44 years. An ultrastructural study of endothelial cells of the microvasculature of the left ventricular myocardium was carried out.Results and discussion. The development of severe burn shock is accompanied by changes in the ultrastructure of the endothelial cells of the blood microvessels of the left ventricular myocardium, which is associated with intracellular degradation and exocytosis. These ultrastructural changes may indicate impairment of vesicular transport in the endothelium of the myocardial microvessels in burn shock. A feature of the ultrastructure of the endothelium was the heterogeneity of the endothelial cells of the blood capillaries due to the revealed dark and light endothelial cells, which differ in the saturation of the cytoplasm with organelles. The new data obtained on changes in the ultrastructure of the endothelium of the microvasculature of the left ventricular myocardium can be informative in the development of approaches to intensive therapy of cardioprotective direction in combustiological patients with burn shock. |
| Databáze: | OpenAIRE |
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