Predictive Value of Weight Loss on Mortality of HIV-Positive Mothers in a Prolonged Breastfeeding Setting
| Autor: | Ai, Koyanagi, Jean H, Humphrey, Lawrence H, Moulton, Robert, Ntozini, Kuda, Mutasa, Peter, Iliff, Andrea J, Ruff, Partson, Zvandasara |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Immunology Breastfeeding Body Mass Index Young Adult Predictive Value of Tests Risk Factors Weight loss Antiretroviral Therapy Highly Active Virology HIV Seropositivity Weight Loss medicine Risk of mortality Humans Clinical Trials/Clinical Studies Young adult Gynecology Obstetrics business.industry Postpartum Period Infant Newborn CD4 Lymphocyte Count Breast Feeding Infectious Diseases Predictive value of tests Income Female medicine.symptom business Breast feeding Body mass index Postpartum period |
| Zdroj: | AIDS Research and Human Retroviruses. 27:1141-1148 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2010.0293 |
| Popis: | HIV-positive lactating women may be at high risk of weight loss due to increased caloric requirements and postpartum physiological weight loss. Ten percent weight loss is associated with a higher risk of mortality in HIV-positive patients and this alone is a criterion for highly active antiretroviral therapy (HAART) initiation where CD4 counts are not available. However, no study has investigated this association in lactating postpartum women. We investigated whether 10% weight loss predicts death in postpartum HIV-positive women. A total of 9207 HIV-negative and 4495 HIV-positive mothers were recruited at delivery. Women were weighed at 6 weeks, 3 months, and every 3 months thereafter for up to 24 months postpartum and data on mortality up to 2 years were collected. The median duration of breastfeeding was longer than 18 months. Among HIV-positive women, the independent predictors of ≥10% weight loss were CD4 cell count, body mass index, and household income. Mortality was up to 7.12 (95% CI 3.47–14.61) times higher in HIV-positive women with ≥10% weight loss than those without weight loss. Ten percent weight loss in postpartum lactating HIV-positive women was significantly predictive of death. Our findings suggest that 10% weight loss is an appropriate criterion for HAART initiation among postpartum breastfeeding women. |
| Databáze: | OpenAIRE |
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