Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman´s Photometric Method
| Autor: | Miroslav Pohanka, Martina Hrabinova, Kamil Kuca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
diagnosis
Nanotechnology lcsh:Chemical technology biosensor Biochemistry Article Analytical Chemistry chemistry.chemical_compound Organophosphate intoxication medicine lcsh:TP1-1185 Electrical and Electronic Engineering Instrumentation Nerve agent Detection limit Chromatography Chemistry carbamate Key features Atomic and Molecular Physics and Optics Cholinesterase inhibition Cost savings Electrochemical gas sensor Biosensor medicine.drug |
| Zdroj: | Sensors (Basel, Switzerland) Sensors; Volume 8; Issue 9; Pages: 5229-5237 Sensors, Vol 8, Iss 9, Pp 5229-5237 (2008) |
| ISSN: | 1424-8220 |
| Popis: | An electrochemical sensor is introduced as a tool applicable for diagnosis of intoxication by cholinesterase inhibitors caused by the well-known nerve agent VX. The traditional Ellman method was chosen for comparison with the sensor's analytical parameters. Both methods are based on estimation of blood cholinesterase inhibition as a marker of intoxication. While Ellman´s method provided a limit of detection of 5.2´10-7 M for blood containing VX, the electrochemical sensor was able to detect 4.0´10-7 M. Good correlation between both methods was observed (R = 0.92). The electrochemical sensor could be considered a convenient tool for a fast yet accurate method, easily available for field as well as laboratory use. Time and cost savings are key features of the sensor-based assay. |
| Databáze: | OpenAIRE |
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