Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition study
| Autor: | Lambertus A. Kiemeney, María Dolores Chirlaque, Carlos González, Nerea Larrañaga, Ruth C. Travis, Jakob Linseisen, María José Sánchez, Per Magne Ueland, Elio Riboli, H. Bas Bueno-de-Mesquita, Heiner Boeing, Theodora Psaltopoulou, Tobias Pischon, Rosario Tumino, Lars Egevad, Paul N. Appleby, Pär Stattin, Domenico Palli, Stein Emil Vollset, Paolo Vineis, J. Ramón Quirós, Sabina Sieri, Mazda Jenab, Eva Ardanaz, Mattias Johansson, Kay-Tee Khaw, Rudolf Kaaks, Göran Hallmans, Timothy J. Key, Sabina Rinaldi, Andrew W. Roddam, Sheila Bingham, Antonia Trichopoulou, Naomi E. Allen, Dimitrios Trichopoulos |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Oncology medicine.medical_specialty Epidemiology Aetiology screening and detection [ONCOL 5] Molecular epidemiology [NCEBP 1] Prostate cancer Folic Acid Risk Factors Translational research [ONCOL 3] Surveys and Questionnaires Internal medicine Determinants in Health and Disease [EBP 1] Humans Medicine Prospective Studies Registries Vitamin B12 Risk factor Prospective cohort study Molecular diagnosis prognosis and monitoring [UMCN 1.2] Chi-Square Distribution Hereditary cancer and cancer-related syndromes [ONCOL 1] business.industry Incidence Prostatic Neoplasms Cancer Middle Aged medicine.disease European Prospective Investigation into Cancer and Nutrition Europe Vitamin B 12 B vitamins Logistic Models Endocrinology Case-Control Studies Relative risk business |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention, 17, 2, pp. 279-85 Cancer Epidemiology, Biomarkers & Prevention, 17, 279-85 |
| ISSN: | 1055-9965 |
| Popis: | Background: Determinants of one-carbon metabolism, such as folate and vitamin B12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (Ptrend = 0.62) or vitamin B12 (Ptrend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B12 concentrations were 1.03 [95% confidence interval (95% CI), 0.92-1.16] and 1.12 (95% CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95% CI, 1.05-2.72, Ptrend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12. Elevated concentrations of vitamin B12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies. (Cancer Epidemiol Biomarkers Prev 2007;17(2):279–85) |
| Databáze: | OpenAIRE |
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