Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
| Autor: | Eduardo Juan Gimeno, Claudio Gustavo Barbeito, F. Confente, Paula Risso, Mario Díaz, Carolina Natalia Zanuzzi, A. G. Duchene, Carolina Wright, Miguel Atilio Risso, A. Lavid, Enrique Leo Portiansky, Fabián Nishida, O. A. Santelices Iglesias |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
040301 veterinary sciences Inflammation Soft Tissue Neoplasms Cat Diseases Pathology and Forensic Medicine Proinflammatory cytokine 0403 veterinary science 03 medical and health sciences Immune system medicine Animals Neoplastic transformation Anaplasia General Veterinary business.industry Mesenchymal stem cell Sarcoma 04 agricultural and veterinary sciences medicine.disease Injection Site Reaction 030104 developmental biology Cyclooxygenase 2 Cancer research Cats Immunohistochemistry medicine.symptom business |
| Zdroj: | Journal of comparative pathology. 165 |
| ISSN: | 1532-3129 |
| Popis: | Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia. |
| Databáze: | OpenAIRE |
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