Urokinase Receptor Regulates Adhesion of Progenitor Cardiac Cells to Vitronectin
| Autor: | I. B. Beloglazova, Z. I. Tsokolaeva, E. V. Parfenova, K. V. Dergilev, E. S. Zubkova, Yu. D. Molokotina, E. I. Ratner |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cell Myocardial Infarction Matrix (biology) General Biochemistry Genetics and Molecular Biology Receptors Urokinase Plasminogen Activator Extracellular matrix Mice 03 medical and health sciences 0302 clinical medicine Cell Adhesion medicine Animals Vitronectin Progenitor Mice Knockout biology Chemistry Myocardium Stem Cells General Medicine Adhesion Cell biology Mice Inbred C57BL Urokinase receptor 030104 developmental biology medicine.anatomical_structure Knockout mouse cardiovascular system biology.protein biological phenomena cell phenomena and immunity 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 167:315-319 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04517-w |
| Popis: | Vitronectin, extracellular matrix protein, plays an important role in embryonic development and in organ and tissue reparation. A unique characteristic of vitronectin is specific binding of various biological molecules, including urokinase receptor (uPAR), extracellular matrix components, adhesion receptors, growth factors, thus supporting the modulation of cell behavior. Vitronectin is in fact not found in intact myocardium, while after infarction its level increases significantly, which correlates with accumulation of uPAR+ progenitor cardiac cells in the focus. The cells isolated from the heart of wild type mice are characterized by higher adhesion to vitronectin than progenitor cardiac cells from the myocardium of uPAR knockout mice. In addition, inhibition of urokinase receptor with specific antibodies on the surface of the progenitor cardiac cells of wild type mice leads to attenuation of their adhesive activity and flattening on vitronectin matrix, which can be important for their distribution in the postinfarction myocardium and realization of the reparative functions. |
| Databáze: | OpenAIRE |
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